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MK-2894 sodium salt
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MK-2894 sodium salt图片
CAS NO:1006036-88-9
规格:98%
分子量:495.49
包装与价格:
包装价格(元)
100mg电议
200mg电议
5mg电议
10mg电议
50mg电议

产品介绍
MK-2894钠盐是第二代EP4拮抗剂。
CAS:1006036-88-9
分子式:C25H21F3NNaO3S
分子量:495.49
纯度:98%
存储:Store at -20°C

Background:

MK-2894 sodium salt is a highly potent and selective second generation EP4 antagonist.IC50 value:Target: EP4MK-2894 exhibits favorable pharmacokinetic profile in a number of preclinical species and potent anti-inflammatory activity in several animal models of pain/inflammation. MK-2894 also shows favorable GI tolerability profile in rats when compared to traditional NSAID indomethacin.




[1]. Blouin M, Han Y, Burch J, Farand J, Mellon C, Gaudreault M, Wrona M, LÉvesque JF, Denis D, Mathieu MC, Stocco R, Vigneault E, Therien A, Clark P, Rowland S, Xu D, O’Neill G, Ducharme Y, Friesen R. The discovery of 4-{1-[({2,5-dimethyl-4-[4-(trifluorometh