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Hydroxocobalamin acetate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Hydroxocobalamin acetate图片
CAS NO:22465-48-1
规格:98%
分子量:1388.39
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Hydroxocobalamin acetate 是一种可注射的天然维生素 B12,具有良好的不良反应特征,可作为治疗维生素 B12 缺乏症(包括恶性贫血)的膳食补充剂。
CAS:22465-48-1
分子式:C64H91CoN13O16P
分子量:1388.39
纯度:98%
存储:Store at -20°C

Background:

Hydroxocobalamin acetate is an injectable naturally occurring form of vitamin B12 with a favorable adverse effect profile, used as a dietary supplement in the treatment of vitamin B12 deficiency including pernicious anemia[1][2]. The cobalt atom of hydroxocobalamin binds cyanide and nitric oxide (NO) and hydroxocobalamin attenuates vascular responses to NO in vitro[3].




[1]. Cheungpasitporn W, et al. High-dose hydroxocobalamin for vasoplegic syndrome causing false blood leak alarm. Clin Kidney J. 2017 Jun;10(3):357-362. [2]. Wang H, et al. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database Syst Rev. 2018 Mar 15;3:CD004655. [3]. Greenberg SS, et al. Hydroxocobalamin (vitamin B12a) prevents and reverses endotoxin-induced hypotension and mortality in rodents: role of nitric oxide. J Pharmacol Exp Ther. 1995 Apr;273(1):257-65.