GSK 366 是一种有效的 kynurenine-3-monooxygenase (KMO) 抑制剂,在人 KMO 和荧光假单胞菌 (Pf)-KMO 中的 IC50 值分别为 2.3 nM 和 0.7 nM。
CAS:1953157-39-5
分子式:C17H16ClN3O4
分子量:361.78
纯度:98%
存储:Store at -20°C
Background:
GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor with IC50s of 2.3 nM and 0.7 nM for human KMO and P. fluorescens-KMO (Pf-KMO), respectively[1].
IC50: 2.3 nM (human KMO), 0.7 nM (Pf-KMO)[1]
[1]. Hutchinson JP, et al. Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase. Nat Commun. 2017 Jun 12;8:15827.