Apramycin sulfate(Nebramycin II)

Molecular Weight (MW)	637.66
Formula	C21H41N5O11.xH2O4S
CAS No.	65710-07-8
Storage	-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO: <1 mg/mL
Water: 100 mg/mL (156.82 mM)
Ethanol: <1 mg/mL
Other info	Chemical Name: (2R,3R,4S,5S,6S)-2-[[(2R,3S,4R,4aR,6S,7R,8aS)-7-amino-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy-4-hydroxy-3-(methylamino)-2,3,4,4a,6,7,8,8a-octahydropyrano[3,2-b]pyran-2-yl]oxy]-5-amino-6-(hydroxymethyl)oxane-3,4-diol sulfuric acid InChi Key: WGLYHYWDYPSNPF-RQFIXDHTSA-N InChi Code: InChI=1S/C21H41N5O11.H2O4S/c1-26-11-14(30)18-8(33-20(11)37-21-16(32)13(29)10(25)9(4-27)34-21)3-7(24)19(36-18)35-17-6(23)2-5(22)12(28)15(17)31;1-5(2,3)4/h5-21,26-32H,2-4,22-25H2,1H3;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11+,12+,13+,14-,15-,16-,17-,18+,19+,20-,21-;/m1./s1 SMILES Code: O[C@H]1[C@@H](O[C@@H]2[C@@H](NC)[C@@H](O)[C@]3([H])[C@@](C[C@@H](N)[C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@H](N)C[C@@H]4N)O3)([H])O2)O[C@H](CO)[C@@H](N)[C@@H]1O.O=S(O)(O)=O
Synonyms	Ai3-29795; Ai3 29795; Ai 3-29795; Apramycin sulphate; Nebramycin II

Molecular Weight (MW)

637.66

Formula

C21H41N5O11.xH2O4S

CAS No.

65710-07-8

Storage

-20℃ for 3 years in powder form

-80℃ for 2 years in solvent

Solubility (In vitro)

DMSO: <1 mg/mL

Water: 100 mg/mL (156.82 mM)

Ethanol: <1 mg/mL

Other info

Chemical Name: (2R,3R,4S,5S,6S)-2-[[(2R,3S,4R,4aR,6S,7R,8aS)-7-amino-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy-4-hydroxy-3-(methylamino)-2,3,4,4a,6,7,8,8a-octahydropyrano[3,2-b]pyran-2-yl]oxy]-5-amino-6-(hydroxymethyl)oxane-3,4-diol sulfuric acid

InChi Key: WGLYHYWDYPSNPF-RQFIXDHTSA-N

InChi Code: InChI=1S/C21H41N5O11.H2O4S/c1-26-11-14(30)18-8(33-20(11)37-21-16(32)13(29)10(25)9(4-27)34-21)3-7(24)19(36-18)35-17-6(23)2-5(22)12(28)15(17)31;1-5(2,3)4/h5-21,26-32H,2-4,22-25H2,1H3;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11+,12+,13+,14-,15-,16-,17-,18+,19+,20-,21-;/m1./s1

SMILES Code: O[C@H]1[C@@H](O[C@@H]2[C@@H](NC)[C@@H](O)[C@]3([H])[C@@](C[C@@H](N)[C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@H](N)C[C@@H]4N)O3)([H])O2)O[C@H](CO)[C@@H](N)[C@@H]1O.O=S(O)(O)=O

Synonyms

Ai3-29795; Ai3 29795; Ai 3-29795; Apramycin sulphate; Nebramycin II

In Vitro	In vitro activity: Apramycin consumption at farm level is most probably driving the increasing occurrence of apramycin/gentamicin cross-resistant [aac(3)-IV positive] E. coli in diseased pigs and healthy finishers at slaughter. Apramycin inhibits A. pleuropneumoniae FMV 87-682 with MIC50 of 8 mg/L. Apramycin (1/4 MIC) in the medium decreases the rate of growth of the bacterial strains tested, and causes the postantibiotic effect (PAE) up to 5 hours. Apramycin significantly reduces the haemolytic activity of A. pleuropneumoniae and affects the capsular material production of this isolate and of one isolate of P. multocida (type A). Apramycin induces translation errors, as assayed by incorporation of leucine, isoleucine and serine, although this effect occurs only to a limited extent, in cell-free systems from Escherichia coli programmed with poly(U). Apramycin inhibits the translocation step of protein synthesis both in vivo, in protoplasts of Bacillus megaterium, and in vitro, in cell-free systems from E. coli.
In Vivo	Apramycin (225 mg/L) totally suppresses mortality and significantly reduces Salmonella excretion in comparison with non-treated chicks.
Animal model	Chicks
Formulation & Dosage	225 mg/L
References	J Antimicrob Chemother. 2006 Jul;58(1):101-7; Int J Antimicrob Agents. 1999 Aug;12(3):229-37; Immunopharmacol Immunotoxicol. 1992;14(1-2):191-205.

In Vitro

In vitro activity: Apramycin consumption at farm level is most probably driving the increasing occurrence of apramycin/gentamicin cross-resistant [aac(3)-IV positive] E. coli in diseased pigs and healthy finishers at slaughter. Apramycin inhibits A. pleuropneumoniae FMV 87-682 with MIC50 of 8 mg/L. Apramycin (1/4 MIC) in the medium decreases the rate of growth of the bacterial strains tested, and causes the postantibiotic effect (PAE) up to 5 hours. Apramycin significantly reduces the haemolytic activity of A. pleuropneumoniae and affects the capsular material production of this isolate and of one isolate of P. multocida (type A). Apramycin induces translation errors, as assayed by incorporation of leucine, isoleucine and serine, although this effect occurs only to a limited extent, in cell-free systems from Escherichia coli programmed with poly(U). Apramycin inhibits the translocation step of protein synthesis both in vivo, in protoplasts of Bacillus megaterium, and in vitro, in cell-free systems from E. coli.

In Vivo

Apramycin (225 mg/L) totally suppresses mortality and significantly reduces Salmonella excretion in comparison with non-treated chicks.

Animal model

Chicks

Formulation & Dosage

225 mg/L

References

J Antimicrob Chemother. 2006 Jul;58(1):101-7; Int J Antimicrob Agents. 1999 Aug;12(3):229-37; Immunopharmacol Immunotoxicol. 1992;14(1-2):191-205.

CAS NO:	65710-07-8
规格:	≥98%

包装	价格(元)
50mg	电议
100mg	电议
250mg	电议
500mg	电议
1g	电议