P217564 is a second-generation active site-targeted covalent irreversible (covalent) inhibitor of USP7. References: Wang F, Wang L, Wu J, Sokirniy I, Nguyen P, Bregnard T, Weinstock J, Mattern M, Bezsonova I, Hancock WW, Kumar S. Active site-targeted covalent irreversible (covalent) inhibitors of USP7 impair the functions of Foxp3+ T-regulatory cells by promoting ubiquitination of Tip60. PLoS One. 2017 Dec 13;12(12):e0189744. doi: 10.1371/journal.pone.0189744. eCollection 2017. PubMed PMID: 29236775; PubMed Central PMCID: PMC5728538.
纯度:≥98%