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ICA 069673
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ICA 069673图片
CAS NO:582323-16-8
包装:50mg
规格:98%
市场价:5364元
分子量:269.63

产品介绍
KV7.2/KV7.3 (KCNQ2/3) channel opener
CAS:582323-16-8
分子式:C11H6ClF2N3O
分子量:269.63
纯度:98%
存储:Store at -20°C

Background:

ICA-069673 is a KCNQ2/Q3 potassium channel activator with an IC50 of 0.69 μM.


ICA-069673 is found to be 20-fold selective for KCNQ2/Q3 over KCNQ3/Q5 and has no measurable activity against a panel of cardiac ion channels (IC50 values >30 μM for hERG, Nav1.5, L type channels, and KCNQ1) as well as no activity on GABA(A) gated channels at 10 μM[1]. ICA-069673 exhibits much stronger effects on KCNQ2 channels, including a large hyperpolarizing shift of the voltage-dependence of activation, an 2-fold enhancement of peak current and pronounced subtype specificity for KCNQ2 over KCNQ3. Based on ICA73 sensitivity of chimeric constructs of the transmembrane segments of KCNQ2 and KCNQ3, this drug appears to interact with the KCNQ2 voltage sensor (S1-S4)[2].


参考文献:
[1]. Wickenden AD, et al. N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator. Mol Pharmacol. 2008 Mar;73(3):977-86. Epub 2007 Dec 18.
[2]. Wang AW, et al. Sequence determinants of subtype-specific actions of KCNQ channel openers. J Physiol. 2017 Feb 1;595(3):663-676.