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Telotristat
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Telotristat图片
CAS NO:1033805-28-5
规格:98%
分子量:546.93
包装与价格:
包装价格(元)
5mg电议
10mg电议
100mg电议

产品介绍
TPH inhibitor
CAS:1033805-28-5
分子式:C25H22ClF3N6O3
分子量:546.93
纯度:98%
存储:Store at -20°C

Background:

Telotristat is a tryptophan hydroxylase 1 (TPH1) inhibitor (IC50 = 16 nM).[1] Dietary administration of telotristat to pregnant and lactating mice decreases serotonin levels in maternal serum and decreases the femoral bone volume to tissue volume ratio, trabecular number and thickness, and cortical tissue mineral density, as well as serum calcium levels, in pups.[2]


Reference:
[1]. Goldberg, D.R., De Lombaert, S., Aiello, R., et al. Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors. Bioorg. Med. Chem. Lett. 26(12), 2855-2860 (2016).
[2]. Weaver, S.R., Fricke, H.P., Xie, C., et al. Peripartum dietary supplementation of a small-molecule inhibitor of tryptophan hydroxylase 1 compromises infant, but not maternal, bone. Am. J. Physiol. Endocrinol. Metab. 215(6), E1133-E1142 (2018).