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KN-92 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
KN-92 hydrochloride图片
CAS NO:1431698-47-3
规格:98%
分子量:493.45
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
200mg电议

产品介绍
Inactive derivative of KN-93,control compound
CAS:1431698-47-3
分子式:C24H26Cl2N2O3S
分子量:493.45
纯度:98%
存储:Store at -20°C

Background:

KN-92 is an inactive analog of KN-93. KN-93 is the CaM kinase II inhibitor. [1]


Hearts were treated with the CaM kinase inhibitor KN-93 or the inactive analog KN-92 (0.5 μM) for 10 min before clofilium exposure. Early afterdepolarizations?(EADs) were largely inhibited by KN-93 contrasted to KN-92. There were little differences in parameters favoring EADs such as monophasic action potential duration or heart rate in KN-92- or KN-93- treated hearts. CaM kinase activity?in situ increased 37% in hearts with EADs compared to hearts without EADs. This increase in CaM kinase activity was prevented by pretreatment with KN-93.?[1]


In vitro, KN-93 potently suppressed rabbit myocardial CaM kinase activity (calculated Ki?≤ 2.58 μM), but the inactive analog KN-92 did not (Ki?>100 μM). The actions of KN-93 and KN-92 on ICa?and other repolarizing K+currents did not illustrate preferential EAD suppression by KN-93. [1]


Reference:
1.  KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J Pharmacol Exp Ther. 1998 Dec;287(3):996-1006.