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BIM 187
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BIM 187图片
CAS NO:137734-88-4
包装:1mg
规格:98%
市场价:3164元
分子量:1069.27

产品介绍
Bombesin/GRP receptor agonist
CAS:137734-88-4
分子式:C53H76N14O10
分子量:1069.27
纯度:98%
存储:Store at -20°C

Background:

Bombesin has common effects on the gastrointestinal tract and feeding behavior. Bombesin acts on two types of receptors including one with high affinity for neuromedin B and another with high affinity for bombesin and gastrin-releasing peptide (GRP). BIM 187is a new peptide of bombesin while BIM 189 is a potent bombesin antagonis.


In vitro: Bombesin stimulates mainly the bombesin high-affinity receptor, and BIM 187 ([D-Phe I ,Leu 8'9 ]litorin-NHe), a new bombesin agonist, stimulates the bombesin/GRP receptor type. [2].


In vivo: To study the mechanism by which bombesin induces satiety, we studied the effect of BIM187 on food intake in rats fed 6 h a day. BIM 187 at 4 μg/kg, reduced food intake at 30 min significantly, but did not change the total 6-h food intake. BIM 189 (10 mg/kg), had no effect on food intake, even at high doses (20 mg/kg). BIM 189 selectively reduced bombesin-induced satiety but had no effect on satiety induced by BIM 187 [2].


Clinical trial: Up to now, BIM 187 is still in the preclinical development stage.


Reference:
[1] Coy D, Wang LH, Jiang NY, Jensen R.  Short chain bombesin pseudopeptides with potent bombesin receptor antagonist activity in rat and guinea pig pancreatic acinar cells. Eur J Pharmacol. 1990 Nov 6;190(1-2):31-8.
[2] Laferrère B,?Leroy F,?Bonhomme G,?Le Gall A,?Basdevant A,?Guy-Grand B.  Effects of bombesin, of a new bombesin agonist (BIM187) and a new antagonist (BIM189) on food intake in rats, in relation to cholecystokinin. Eur J Pharmacol.?1992 Apr 29;215(1):23-8.