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Mal-PEG2-Val-Cit-PAB-OH
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:2055041-38-6
包装:50mg, 100mg, 250mg
规格:≥98%

产品介绍

Mal-PEG2-Val-Cit-PAB-OH is an peptide PEG Linker that may be used in antibody drug conjugation (ADC). The Val-Cit group is specifically cleaved by cathepsin B. Because this enzyme is only present in the lysosome, the ADC payload will be released only within the cell. The hydrophilic PEG spacer increases solubility in aqueous media. References: Sano K, Nakajima T, Miyazaki K, Ohuchi Y, Ikegami T, Choyke PL, Kobayashi H. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. doi: 10.1021/bc400050k. Epub 2013 May 3. PubMed PMID: 23600922; PubMed Central PMCID: PMC3674550.

纯度:≥98%

CAS:2055041-38-6