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Liothyronine Sodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Liothyronine Sodium图片
CAS NO:55-06-1
包装:50mg
规格:98%
市场价:604元
分子量:672.96

产品介绍
Thyroid hormone (T3) analog
CAS:55-06-1
分子式:C15H12I3NO4.Na
分子量:672.96
纯度:98%
存储:Store at -20°C

Background:

Liothyronine sodium is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity.


Liothyronine (T3, 100 nM) stimulates the proliferation of hepatocarcinema cells in which TRβ1 is overexpressed[1]. Liothyronine binds to human β1 thyroid hormone receptor (hTRβ1), and change its conformation. Liothyronine promotes growth, induces differentiation and regualtes metabolic effects[2].


参考文献:
[1]. Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94.
[2]. Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92.