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Ansamitocin P-3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ansamitocin P-3图片
CAS NO:66547-09-9
规格:98%
分子量:635.14
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
Inhibitor of tublin spiralization,maytansine analog
CAS:66547-09-9
分子式:C32H43ClN2O9
分子量:635.14
纯度:98%
存储:Store at -20°C

Background:

Ansamitocin P-3, a natural product, is maytansinoid which showed potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29 with ED50 of 4 x 10 -7, 4 x 10 – 7 μg/ml, respectively. [1]
Cytotoxic agents remain an important strategy in chemotherapy. In an activity-directed isolation and identification, ansamitocin P-3 was obtained from the active methanol extracts of two mosses.
Furthermore, the compound showed great cytotoxicity against several tumor cells. [1]
Ansamitocin P-3 is a maytansinoid isolated in very low yield from two members of the moss family Thuidiaceae, Claopodium crispifolium (Hook.) Ren. & Card. and Anomodon attenuatus (Hedw.) Hueb. Further biological evaluation of ansainitocin P-3 showed potent cytotoxicity against the human solid tumor cell line systems A-549 lung carcinoma cells, HT-29 colon adenocarcinoma cells and MCF-7 breast adenocarcinoma cells at ED50 of 4 x 10 -7, 4 x 10 - 7, 2 x 10 -6 μg/ml. respectively. [2]
Ansamitocin P-3 exhibited inhibition of cilia regeneration of partially deciliated Tetrahymena. The regeneration of cilia in Tetrahymena was assayed by observing recovery of motility of the deciliated cells which are nonmotile after being deciliated. After 60 min of incubation, more than 95% of partially deciliated Tetrahymena cells in the recovery buffer were fully motile. Ansamitocin P-3 completely inhibited cilia regeneration of Tetrahymena at 1 μM. Moreover, recovery of motility of partially deciliated cells after release from inhibition by 2 μM ansamitocin P-3. [2]
参考文献:
[1]. Suwanborirux, K., et al. "Ansamitocin P-3, a maytansinoid, fromClaopodium crispifolium andAnomodon attenuatus or associated actinomycetes."Experientia 46.1 (1990): 117-120.
[2]. Tanida, Seiichi, Eiji Higashide, and Masahiko Yoneda. "Inhibition of cilia regeneration of Tetrahymena by ansamitocins, new antitumor antibiotics."Antimicrobial agents and chemotherapy 16.1 (1979): 101.