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Flavin adenine dinucleotide disodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Flavin adenine dinucleotide disodium图片
CAS NO:84366-81-4
规格:98%
分子量:829.51
包装与价格:
包装价格(元)
100mg电议
500mg电议

产品介绍
C27H31N9Na2O15P2
CAS:84366-81-4
分子式:C27H31N9Na2O15P2
分子量:829.51
纯度:98%
存储:Store at -20°C

Background:

Flavin Adenine Dinucleotide Disodium is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.


Poly(Flavin Adenine Dinucleotide, FAD) characterized by an additional polymer-type redox reaction is a highly effective electrocatalyst for NADH oxidation: operating at the lowest potentials reported for NADH transducers (0.00 V, pH 7.4), poly(FAD) is characterized by the electrochemical rate constant of 1.8 ± 0.6×10-3 cm/s, which is at the level of the NADH mass-transfer constant. Poly(FAD)-modified electrodes are characterized by the dramatically improved stability and, is the most advantageous NADH transducers for analytical chemistry[2].


With flavin adenine dinucleotide (2 mg/kg), the chlorpromazine (CPZ)-induced decrease in ventricular fibrillation threshold (VFT) is significantly cancelled. Flavin Adenine Dinucleotide cancels the effect of CPZ on canine heart mitochondria. After injection of Flavin Adenine Dinucleotide, the dogs show a transient hypotension within 10 min, then their blood pressures recover to the initial level. Flavin Adenine Dinucleotide also prevents mitochondrial dysfunction induced by chlorpromazine[1].


参考文献:
[1]. Sugiyama S, et al. Protection of chlorpromazine-induced arrhythmia by flavin-adenine-dinucleotide in canine heart. Jpn Heart J. 1979 Sep;20(5):657-65.
[2]. Karyakin AA, et al. Electropolymerized flavin adenine dinucleotide as an advanced NADH transducer. Anal Chem. 2004 Apr 1;76(7):2004-9.