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Limaprost
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Limaprost图片
CAS NO:74397-12-9
规格:98%
分子量:380.52
包装与价格:
包装价格(元)
100mg电议
200mg电议
2mg电议
5mg电议
10mg电议
50mg电议

产品介绍
Limaprost(OP1206)是PGE1类似物,是血小板粘附抑制剂。
CAS:74397-12-9
分子式:C22H36O5
分子量:380.52
纯度:98%
存储:Store at -20°C

Background:

Limaprost(OP1206) is a PGE1 analog and potent platelet adhesion inhibitor.Target: OthersLimaprost, an alprostadil (prostaglandin E1) analogue, is a vasodilator that increases blood flow and inhibits platelet aggregation. Limaprost is a n analog of PGE1 with structural modifications intended to give a prolonged half-life and greater potency. It is orally active in both guinea pigs and rats at doses of 100 mg/kg as an inhibitor of ADP and collagen induced platelet aggregation. It is 10-1,000 times more potent than PGE1 as a platelet adhesive inhibitor, measured in vitro. Intra-coronary injection (100 ng/kg) or intravenous injection (3 mg/kg) in anesthetized dogs causes vasodilation and increased coronary blood flow by 60-80%. Significant hypotensive effects were seen at 100 and 300 mg/kg orally in rats [1].




[1]. Tsuboi, T., et al., Pharmacological evaluation of OP 1206, a prostaglandin E1 derivative, as an antianginal agent. Arch Int Pharmacodyn Ther, 1980. 247(1): p. 89-102.