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IACS-10759 Hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
IACS-10759 Hydrochloride图片
CAS NO:1807523-99-4
规格:98%
分子量:599.02
包装与价格:
包装价格(元)
200mg电议
500mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
IACS-10759 Hydrochloride 是氧化磷酸化 (OXPHOS) 复合物I的有效抑制剂。
CAS:1807523-99-4
分子式:C25H26ClF3N6O4S
分子量:599.02
纯度:98%
存储:Store at -20°C

Background:

IACS-10759 Hydrochloride is a potent inhibitor of complex I of oxidative phosphorylation (OXPHOS). OXPHOS[1]


IACS-10759 inhibits the conversion of NADH to NAD+ in an immunoprecipitated complex I assay at low nM concentrations[1].


IACS-10759 is orally bioavailable with excellent physicochemical properties in preclinical species and achieves significant in vivo efficacy with daily oral dosing of 10-25 mg/kg. There is a >50 day extension of median survival in an orthotopic AML cell line xenograft and robust regression in DLBCL and GBM xenograft models[1].


[1]. Protopopova M. IACS-10759: A novel OXPHOS inhibitor which selectively kill tumors with metabolic vulnerabilities. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4380. doi:10.1158/1538-7445.AM2015-4380