HSL-IN-1 (compound 24b) 是一种有效且具有口服活性的激素敏感脂肪酶 (HSL) 抑制剂 (IC50=2 nM),显著降低了活性代谢物负荷。
CAS:2095156-13-9
分子式:C19H13BClF3N2O4
分子量:436.58
纯度:98%
存储:Store at -20°C
Background:
HSL-IN-1 (compound 24b) is a potent and orally active hormone sensitive lipase (HSL) inhibitor (IC50=2 nM) with a significantly reduced reactive metabolite liability[1].
IC50: 2 nM (Hormone sensitive lipase)[1]
[1]. Ogiyama T, et al. Identification of a novel hormone sensitive lipase inhibitor with a reduced potential of reactive metabolites formation. Bioorg Med Chem. 2017 Apr 1;25(7):2234-2243.