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Beclometasone(Beclomethasone)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Beclometasone(Beclomethasone)图片
CAS NO:4419-39-0
规格:98%
分子量:408.92
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议

产品介绍
Beclometasone(Beclomethasone)是一种糖皮质激素受体(glucocorticoidreceptor)激动剂。
CAS:4419-39-0
分子式:C22H29ClO5
分子量:408.92
纯度:98%
存储:Store at -20°C

Background:

Beclometasone (Beclomethasone) is a prototype glucocorticoid receptor agonist.


An inhibition of the normal physiological neutrophil migration and of neutrophil chemotaxis directed by wounding-induced inflammation is detected at 4 h after administration of 25 μM Beclomethasone. Tumour cell invasion and micrometastasis is also reduced in embryos incubated in 25 μM Beclomethasone 4 h before implantation. In addition, the lysyl oxidase inhibitor β-aminoproprionitrile (βAPN) largely reduces fibrillar collagen and enhances the CHT-TF transmigration of neutrophils, leading to a significant increase of tumour cell invasion and subsequent formation of micrometastases. Notably, βAPN inhibits neutrophil chemotaxis induced by inflammation, indicating that the increase of tumour cell invasion in βAPN-treated embryos is correlated with enhanced non-pathological neutrophil migration, but not with inflammation[1].



[1]. He S, et al. Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model. J Pathol. 2012 Aug;227(4):431-45.