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SPB
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SPB图片
CAS NO:858128-57-1
规格:98%
分子量:385.32
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
SPB是肺表面活性物质的主要成分,对正常肺功能至关重要。
CAS:858128-57-1
分子式:C19H15NO8
分子量:385.32
纯度:98%
存储:Store at -20°C

Background:

SPB is a key component of pulmonary surfactant, essential for normal lung function.



Human SP-B gene but not mouse SP-B is expressed in the lung of hTG SP-B-C and SP-B-T mice. For infected SP-B-C mice, the levels of bioluminescence increase rapidly from 0 to 24h after infection, remains high between 24 and 32 h, and then decreases; the bioluminescence levels are significantly lower (p<0.01) in the CMC2.24 treated group from 24 to 48 h after infection. In infected SP-B-T mice, the peak time of bioluminescence is at 12 h after infection, then the level decreases slowly. Lung tissues from of infected SP-B-C mice showed more apoptotic cells compared to infected SP-B-T mice. CMC2.24 treated SP-B-C and SP-B-T mice have decreased MMP-2, -9, and -12 activities compared to their respective untreated groups[1].


[1]. Xu Y, et al. DIFFERENTIAL SUSCEPTIBILITY OF HUMAN SP-B GENETIC VARIANTS ON LUNG INJURY CAUSED BY BACTERIAL PNEUMONIA AND THE EFFECT OF A CHEMICALLY MODIFIED CURCUMIN. Shock. 2016 Apr;45(4):375-84.