E-7386是一种口服有效的CBP/β-连环蛋白(CBP/beta-catenin)调节剂。
CAS：1799824-08-0
分子式：C39H48FN9O4
分子量：725.85
纯度：98%
存储：Store at -20°C

Background:

E-7386 is an orally active CBP/beta-catenin modulator.

E-7386 is an orally active CBP/beta-catenin modulator which can induce T cells infiltration into tumor and enhance antitumor activity of anti-PD-1 mAb in Wnt1 tumor syngeneic mice model. E-7386 shows significant antitumor activity in Wnt1 model. Infiltration of T cells is limited in vehicle control group, but T cell infiltration into tumors is clearly observed in E-7386 treatment group[1].

[1]. Yusaku Hori, et al. E7386, an orally active CBP/beta-catenin modulator, induces T cells infiltration into tumor and enhances antitumor activity of anti-PD-1 mAb in Wnt1 tumor syngeneic mice model. Cancer Res 2017;77(13 Suppl):Abstract nr 5172.