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IBR2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
IBR2图片
CAS NO:313526-24-8
规格:98%
分子量:400.49
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
IBR2是一种特异性RAD51抑制剂。
CAS:313526-24-8
分子式:C24H20N2O2S
分子量:400.49
纯度:98%
存储:Store at -20°C

Background:

IBR2 is a specific RAD51 inhibitor.


IBR2 shows interesting RAD51 inhibition activities. RAD51 is rapidly degraded in IBR2-treated cancer cells, and the homologous recombination repair is impaired, subsequently leading to cell death. The IC50 values of the original IBR2 are in the range of 12-20 µM for most tested cancer cell lines. IBR2 can inhibit the growth of triple-negative human breast cancer cell line MBA-MD-468 with an IC50 of 14.8 µM[1].



[1]. Zhu J, et al. Synthesis, molecular modeling, and biological evaluation of novel RAD51 inhibitors. Eur J Med Chem. 2015;96:196-208.