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GSK2850163
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK2850163图片
CAS NO:2121989-91-9
规格:98%
分子量:446.41
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
GSK2850163是一个新型的肌醇需要酶-1α(IRE1α)抑制剂,它可抑制IRE1α的激酶活性和RNA酶活性,其IC50值分别为20和200nM。
CAS:2121989-91-9
分子式:C24H29Cl2N3O
分子量:446.41
纯度:98%
存储:Store at -20°C

Background:

GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC50s of 20 and 200 nM, respectively.


GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC50s of 20 and 200 nM, respectively. The increased autophosphorylation of IRE1α could be reduced in a dose-dependent manner by GSK2850163. Increasing concentrations of GSK2850163 are capable of reducing the increased XBP 1 transcriptional activity. Two additional kinases are weakly inhibited by GSK2850163: Ron (IC50=4.4 μM) and FGFR1 V561M (IC50=17 μM)[1].



[1]. Nestor O. Concha, et al. Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1α Endoribonuclease Activity. Molecular Pharmacology December 2015, 88 (6) 1011-1023.