您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Selitrectinib(LOXO-195)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Selitrectinib(LOXO-195)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Selitrectinib(LOXO-195)图片
CAS NO:2097002-61-2
规格:98%
分子量:380.42
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Selitrectinib(LOXO-195)是原肌凝蛋白相关激酶(TRK)的一个二代抑制剂,其对TRKA和TRKC的IC50值分别为0.6nM和<2.5nM。
CAS:2097002-61-2
分子式:C20H21FN6O
分子量:380.42
纯度:98%
存储:Store at -20°C

Background:

Selitrectinib (LOXO-195) is a next-generation TRK kinase inhibitor (TKI), with IC50s of 0.6 nM,<2.5 nM for TRKA and TRKC respectively.


Selitrectinib (LOXO-195) demonstrates strong binding to the wild-type TRKA, TRKB and TRKC kinase domains. Selitrectinib (LOXO-195) has potent (IC50<1 nM) inhibitory activity in kinase enzyme assays. Importantly, Selitrectinib (LOXO-195) achieves low nanomolar inhibitory activity against TRKA G595R, TRKC G623R, and TRKA G667C, with IC50s ranging from 2.0-9.8 nM. 228 individual kinases in vitro are profiled at a Selitrectinib (LOXO-195) concentration of 1 μM, which is