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BQR-695(NVP-BQR695)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BQR-695(NVP-BQR695)图片
CAS NO:1513879-21-4
规格:98%
分子量:352.39
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
200mg电议

产品介绍
BQR-695是一种PI4KIIIβ抑制剂,对于人类和疟原虫PI4KIIIβ的IC50值分别为80和3.5nM。
CAS:1513879-21-4
分子式:C19H20N4O3
分子量:352.39
纯度:98%
存储:Store at -20°C

Background:

BQR-695 is a PI4KIIIβ inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.


Treatment with 0.5 μM of either KAI407 or BQR695 causes GFP-PHOsh2 to redistribute to the parasite plasma membrane, consistent with depletion of intracellular PI4P upon inhibition of PfPI4K function. BQR695 shows no evidence of toxicity against mature red blood cells (RBCs), induces a schizont-stage arrest indistinguishable from that observed in imidazopyrazine-treated parasites and exhibits cross-resistance with the imidazopyrazine-resistant lines[2].



[1]. Fowler ML, et al. Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11. Protein Sci. 2016 Apr;25(4):826-39. [2]. McNamara CW, et al. Targeting Plasmodium PI(4)K to eliminate malaria. Nature. 2013 Dec 12;504(7479):248-253.