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PGS-IN-1(KME-4)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PGS-IN-1(KME-4)图片
CAS NO:102271-49-8
规格:98%
分子量:302.41
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
20mg电议

产品介绍
PGS-IN-1是有效的前列腺素合成酶(prostaglandinsynthetase)抑制剂,IC50值为0.28μM;也可抑制5-脂肪氧合酶(5-lipoxygenase)的活性,IC50值为1.05μM。
CAS:102271-49-8
分子式:C19H26O3
分子量:302.41
纯度:98%
存储:Store at -20°C

Background:

PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS) with an IC50 of 0.28 μM; also inhibits 5-lipoxygenase with an IC50 of 1.05 μM.


The synthesized α-benzulidene-γ-butyrolactones are pure isomers (either cis or trans). PGS-IN-1 is the trans isomer. PGS-IN-1 exhibits potent antiinflammatrory and PGS inhibitory activity (IC50=0.28 μM). PGS-IN-1 also shows potent inhibitory activity against 5-lipoxygenase (IC50=1.05 μM)[1].



[1]. Katsumi I, et al. Studies on styrene derivatives. I. Synthesis and antiinflammatory activities of alpha-benzylidene-gamma-butyrolactone derivatives. Chem Pharm Bull (Tokyo). 1986 Jan;34(1):121-9.