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KY-556(N556)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
KY-556(N556)图片
CAS NO:110816-78-9
规格:98%
分子量:725.57
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
20mg电议

产品介绍
KY-556是一种针对过敏性疾病的具有口服活性的色甘酸二钠(DSCG)的前药。
CAS:110816-78-9
分子式:C33H38Cl2N2O12
分子量:725.57
纯度:98%
存储:Store at -20°C

Background:

KY-556 is a promising and orally-active pro-drug of disodium cromoglycate (DSCG) against allergic diseases.



The oral anti-allergic effect of KY-556 (N-556) is investigated. N-556 (10-100 mg/kg, p.o.) inhibits dose-dependently the 48-hr homologous passive cutaneous anaphylaxis (PCA) in rats, and the duration of action is longer than that of intravenous Disodium cromoglycate (DSCG). N-556 (20 and 100 mg/kg once a day for 20 consecutive days, p.o.) tends to inhibit the histamine release from actively sensitized rat lung fragments. N-556 (100 mg/kg, p.o.) shows the prolongation of survival time in the rat systemic anaphylaxis. N-556 (100 mg/kg, p.o.) significantly inhibits the increased airway resistance in experimental asthma in rats[1].


[1]. Nakamura S, et al. Effects of N-556 on experimental allergy models in rats. Arerugi. 1990 Dec;39(12):1621-8.