Thymine是DNA的四个碱基之一,可以作为癌症治疗中5-氟尿嘧啶(5-FU)的靶标,其Km值为2.3μM。
CAS:65-71-4
分子式:C5H6N2O2
分子量:126.11
纯度:98%
存储:Store at -20°C
Background:
Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM.
[1]. Tuchman M, et al. Effects of uridine and thymidine on the degradation of 5-fluorouracil, uracil, and thymine by rat liver dihydropyrimidine dehydrogenase. Cancer Res. 1985 Nov;45(11 Pt 1):5553-6.