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AA26-9
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AA26-9图片
CAS NO:1312782-34-5
规格:98%
分子量:166.18
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
AA26-9是有效广谱的丝氨酸水解酶抑制剂。
CAS:1312782-34-5
分子式:C7H10N4O
分子量:166.18
纯度:98%
存储:Store at -20°C

Background:

AA26-9 is a potent and broad spectrum serine hydrolase inhibitor.


AA26-9 is synthesized based on a piperazine scaffold shown previously to inhibit serine hydrolases in the context of p-nitrophenoxy carbamate. AA26-9-inhibited enzymes originated from diverse functional subclasses of serine hydrolases, including lipases/phospholipases (AADACL1, ABHD6, ESD, FAAH, PAFAH2, LYPLA3), peptidases (APEH, PRCP, CTSA), thioesterases (LYPLA1, LYPLA2), and uncharacterized enzymes (ABHD11, ABHD13, BAT5). AA26-9 inhibits one of its enzyme targets LYPLA1 by covalent carbamoylation of the enzyme’s serine nucleophile (S114). AA26-9 inhibits 1/3 of the over 40 serine hydrolase found in T-cells[1].



[1]. Adibekian A, et al. Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors. Nat Chem Biol. 2011 May 15;7(7):469-78.