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NGP555
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NGP555图片
CAS NO:1304630-27-0
规格:98%
分子量:406.52
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
NGP555是一个γ-分泌酶(γ-secretase)调节剂。
CAS:1304630-27-0
分子式:C23H23FN4S
分子量:406.52
纯度:98%
存储:Store at -20°C

Background:

NGP555 is a γ-secretase modulator.


NGP555 potently lowers Aβ42 in cell cultures (9 nM) while increasing shorter forms of Aβ[1].


NGP555 significantly lowers Aβ42 in the cerebrospinal fluid (CSF) at time points from 8 to10 hours post dose, panel B shows that reduction of Aβ cerebrospinal fluid (CSF) levels is significant at 3.75 mg/kg of NGP555 and above, and panel C shows an increase in Aβ38 levels at 15 mg/kg of NGP555 and above. When combining the reduction of Aβ42 with an increase in Aβ38, NGP555 is effective at raising CSF Aβ38/42 ratio at 1.87 mg/kg and above (panel D). NGP555-treated Tg mice show a significant protection from decline in performance with >65% less decline (P<0.005) when comparing the differential of Tg to non-Tg vehicle-treated mice. NGP555 also shows good oral bioavailability and is brain-penetrant with a brain:plasma ratio of