| CAS NO: | 633-65-8 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 500mg | 电议 |
| 1g | 电议 |
| 2g | 电议 |
| 5g | 电议 |
| 10g | 电议 |
| Molecular Weight (MW) | 371.81 |
|---|---|
| Formula | C20H18ClNO4 |
| CAS No. | 633-65-8 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: > 10 mM |
| Water: NA | |
| Ethanol: NA | |
| Other info | Chemical Name: 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium chloride InChi Key: VKJGBAJNNALVAV-UHFFFAOYSA-M InChi Code: InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1 SMILES Code: COC1=C(OC)C2=C[N+]3=C(C(C(CC3)=C4)=CC5=C4OCO5)C=C2C=C1.[Cl-] |
| Synonyms | Natural Yellow 18; Berberinium chloride; BBR; Umbellatine |
| In Vitro | In vitro activity: Berberine was found to be able to increase the glucose consumption and/or glucose uptake in the absence of insulin in adipocytes, hepatocytes and myotubes. The enhancing glucose metabolism of berberine might be due to glycolysis stimulation, which was related to the mitochondria oxidation inhibition. Berberine might also act as an alpha-glucosidase inhibitor. In addition, berberine inhibited activities of disaccharidases and decreased glucose transportation cross the intestinal epithelium. |
|---|---|
| In Vivo | In diet-induced obese rats, berberine was found to reduce insulin resistance, similar to metformin. Berberin and metformin improved insulin resistance and liver glycogen level in insulin resistance models, but had no effect on insulin, blood glucose, lipid levels and muscle triglyceride depots |
| Animal model | Rats |
| Formulation & Dosage | NA |
| References | Metabolism.2008 May;57(5):712-7; Zhongguo Zhong Xi Yi Jie He Za Zhi.1997 Mar;17(3):162-4. |
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