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BMP-22
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BMP-22图片
CAS NO:1306684-90-1
规格:98%
分子量:382.5
包装与价格:
包装价格(元)
25mg电议
1mg电议
5mg电议
10mg电议

产品介绍
BMP-22 is an inhibitor of autotaxin (IC50 = 170 nM).
CAS:1306684-90-1
分子式:C22H39O3P
分子量:382.5
纯度:98%
存储:Store at -20°C

Background:

BMP-22 is an inhibitor of autotaxin (IC50 = 170 nM). It is selective for autotaxin over the phosphodiesterases NPP6 and NPP7 at 10 μM. BMP-22 (0.1-1,000 nM) inhibits autotaxin-mediated production of lysophosphatidic acid (LPA) from lysophosphatidylcholine in vitro in a concentration-dependent manner. It inhibits LPC-dependent MM1 cell invasion of a human umbilical vein endothelial cell (HUVEC) monolayer. BMP-22 (0.5 mg/kg per day) decreases the number of lung metastatic foci in a B16/F10 syngeneic mouse melanoma model of lung metastasis.