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2'2'-cGAMP(sodium salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
2'2'-cGAMP(sodium salt)图片
CAS NO:1465774-27-9
规格:98%
分子量:720.4
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
2'2'-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds.
CAS:1465774-27-9
分子式:C20H24N10O13P2.2Na
分子量:720.4
纯度:98%
存储:Store at -20°C

Background:

2’2’-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2’5’-phosphodiester bonds. It binds to the adapter protein stimulator of interferon genes , which is a component of the innate immune response that activates the type I interferon pathway when bound to cyclic dinucleotides. 2’2-cGAMP shows weaker binding to STING than 2’3’-cGAMP but binds more strongly than 3’3’-cGAMP , cyclic di-GMP , or 3’2’-cGAMP, which bind in the micromolar range (Kds = 1.04, 1.21, or 1.61 µM, respectively). Despite weaker binding, 2’2’-cGAMP induces IFN-β production in the same concentration range as 2’3’-cGAMP (EC50s = 15.8 and 19.4 nM, respectively, in L929 cells).