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Tesaglitazar
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tesaglitazar图片
CAS NO:251565-85-2
规格:98%
分子量:408.47
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Dual-specificity PPARα/γ agonist
CAS:251565-85-2
分子式:C20H24O7S
分子量:408.47
纯度:98%
存储:Store at -20°C

Background:

Tesaglitazar is a dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist that is more potent on PPARγ than on PPARα, with EC50s of 13.4 μM and 3.6 μM for rat PPARα and human PPARα, respectively, and approximately 0.2 μM for both rat and human PPARγ. Tesaglitazar induces interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats[1].


参考文献:
[1]. Hellmold H, et al. Tesaglitazar, a PPARalpha/gamma agonist, induces interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats. Toxicol Sci. 2007 Jul;98(1):63-74.