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BAN ORL 24
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BAN ORL 24图片
CAS NO:475150-69-7
规格:98%
分子量:506.51
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议

产品介绍
NOP receptor antagonist, potent and selective
CAS:475150-69-7
分子式:C27H37Cl2N3O2
分子量:506.51
纯度:98%
存储:Store at -20°C

Background:

BAN ORL24 is a selective inhibitor of NOP with pK(i) value of 9.62 [1].
NOP (nociceptin/orphanin FQ (N/OFQ) peptide receptor) is a G protein coupled receptor and plays an important role in regulating many brain activities[2].
BAN ORL24 is a potent NOP inhibitor and has the highest affinity compared with other NOP inhibitors. When tested with CHO (hNOP) cells, administration of BAN ORL24 showed high affinity to cell membrane and higher selective compared with classical opioid receptors [1]. In SG neuron heterologously expressing NOP receptors with an enhanced basal facilitation ratio, BAN ORL24 treatment for 50 seconds enhanced the Ca2+ current amplitude for both prepulse and postpulse [3].
In the mouse tail withdrawal assay, administration of BAN ORL24 (10 mg/kg) combined with N/OFQ (1 nmol) antagonized the pronociceptive and antinociceptive effects of given supraspinally and spinally, respectively. Under the same experimental conditions BAN ORL24 did not affect the antinociceptive action of 3 nmol endomorphin-1 injected intrathecally [1].
参考文献:
[1].Fischetti, C., et al., Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist Compound 24. Eur J Pharmacol, 2009. 614(1-3): p. 50-7.
[2].Donica, C.L., et al., Cellular mechanisms of nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor regulation and heterologous regulation by N/OFQ. Mol Pharmacol, 2013. 83(5): p. 907-18.
[3].Mahmoud, S., et al., Modulation of silent and constitutively active nociceptin/orphanin FQ receptors by potent receptor antagonists and Na+ ions in rat sympathetic neurons. Mol Pharmacol, 2010. 77(5): p. 804-17.