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NBQX
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NBQX图片
CAS NO:118876-58-7
规格:98%
分子量:336.28
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
AMPA receptor antagonist
CAS:118876-58-7
分子式:C12H8N4O6S
分子量:336.28
纯度:98%
存储:Store at -20°C

Background:

NBQX is a highly selective and competitive AMPA receptor antagonist.


NBQX has a high affinity for AMPA and kainate binding sites with little or no affinity for the glutamate recognition site on the NMDA receptor complex[1].


NBQX is neuroprotective in a focal ischaemia model in the rat when given as an i.v. bolus dose of 30 mg/kg at the time of MCA occlusion and again at 1 h post occlusion[1]. NBQX provides potent anticonvulsant protection against AMPA. The ED50 values for the protection against AMPA-induced seizures by NBQX (30 min, i.p.) is 23.6 (11.6- 48.0)[2].


参考文献:
[1]. Fukushima K, et al. Characterization of Human Hippocampal Neural Stem/Progenitor Cells and Their Application to Physiologically Relevant Assays for Multiple Ionotropic Glutamate Receptors. J Biomol Screen. 2014 Sep; 19(8):1174-84.