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M40
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
M40图片
CAS NO:143896-17-7
包装:1mg
规格:98%
市场价:1834元
分子量:1981.33

产品介绍
galanin receptor antagonist
CAS:143896-17-7
分子式:C94H145N23O24
分子量:1981.33
纯度:98%
存储:Store at -20°C

Background:

M40 is a potent, non-selective galanin receptor antagonist.


M40 (1 μM) displaces [mono[125IJodo-Tyr26]galanin from binding sites in the hippocampus, hypothalamus, and spinal cord. M40 has a lower affinity than galanin for all membranes. The IC50 values are 6 nM in the hippocampus, 15 nM in the hypothalamus, 12 nM in the spinal cord, and 3 nM in the insulinoma cells. M40 (1 μM) completely blocks 125I-labeled galanin-binding sites[1].


参考文献:
[1]. Bartfai T, et al. Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes. Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11287-91.