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Alfacalcidol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Alfacalcidol图片
CAS NO:41294-56-8
规格:98%
分子量:400.65
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
100mg电议
500mg电议

产品介绍
Bone resorption inhibitor
CAS:41294-56-8
分子式:C27H44O2
分子量:400.65
纯度:98%
存储:Store at -20°C

Background:

Alfacalcidol is an analogue of Vitamin D and a potent inhibitor of bone resorption [1].


Alfacalcidol has been revealed to play a part in bone and mineral homeostasis via binding to the VDR (vitamin D receptor) in calcium-related target organs, such as intestine, bone, kidney and parathyroid gland. In addition, in a high bone-turnover state after OVX, Alfacalcidol has been reported to inhibit osteoclastic bone resorption at pharmacological doses that do not cause hypercalcemia. Apart from these, Alfacalcidol has shown the stimulative effect to the bone formation. Furthermore, Alfacalcidol has been found to enhance bone mass and bone strength at given serum and urinary calcium levels in the OVX model.


参考文献:
[1] Shiraishi A1, Takeda S, Masaki T, Higuchi Y, Uchiyama Y, Kubodera N, Sato K, Ikeda K, Nakamura T, Matsumoto T, Ogata E. Alfacalcidol inhibits bone resorption and stimulates formation in an ovariectomized rat model of osteoporosis: distinct actions from estrogen. J Bone Miner Res. 2000 Apr;15(4):770-9.