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CCT007093
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CCT007093图片
CAS NO:176957-55-4
规格:98%
分子量:272.39
包装与价格:
包装价格(元)
10mg电议
25mg电议

产品介绍
PPM1D inhibitor
CAS:176957-55-4
分子式:C15H12OS2
分子量:272.39
纯度:98%
存储:Store at -20°C

Background:

CCT007093 is a small-molecule chemical inhibitor of PPM1D with IC50 value of 8.4μM [1].


CCT007093 is a thienylidene cyclopentanone and shows a potent inhibition of PPM1D in the in vitro assay when using the recombinant phospho-P38 as a substrate. In cellular assay, CCT007093 shows specificity for MCF-7 cells over HeLa cells. It reduces 40% viability of the cells after 2 days. It is found that the cell death induced by CCT007093 is dependent on P38 kinase activity. CCT007093 mimics the effect of PPM1D RNAi in activating P38 kinase. It induces P38 phosphorylation at 4 h post-exposure in MCF-7 cells and the loss of viability can be rescued by SB203580, the specific P38 inhibitor [1].


参考文献:
[1] Rayter S, Elliott R, Travers J, Rowlands MG, Richardson TB, Boxall K, Jones K, Linardopoulos S, Workman P, Aherne W, Lord CJ, Ashworth A. A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D. Oncogene. 2008 Feb 14;27(8):1036-44.