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6-Bnz-cAMP sodium salt
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
6-Bnz-cAMP sodium salt图片
CAS NO:1135306-29-4
规格:98%
分子量:455.29
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
cAMP analog,PKA activator
CAS:1135306-29-4
分子式:C17H15N5NaO7P
分子量:455.29
纯度:98%
存储:Store at -20°C

Background:

6-Bnz-cAMP is a PKA-selective activator. It regulates the PKA dependent signaling pathways.


Like PKA contains an evolutionally conserved cAMP-binding domain that acts as a molecular switch for sensing intracellular second messenger cAMP levels to control diverse biological functions. CAMP response element-binding protein (CREB) is the well-known direct target protein of PKA. Phosphorylation of CREB (pCREB) by PKA has been shown to be involved in regulating osteoblast differentiation.


The proliferative signaling pathway which activated by the 6-Bnz-cAMP involves activation of the epidermal growth factor receptor and ERK1/2. Extending the duration of PKA-dependent ERK1/2 activation and converted cAMP from a proliferative into an anti-proliferative, neurite outgrowth- promoting signal.


6-Bnz-cAMP can promote not only differentiation and mineralization, but also initial cell adhesion.6-Bnz-cAMP is able to induce osteogenic differentiation of MC3T3-E1 cells. Moreover 6-Bnz-cAMP may facilitate release kinetic from a tissue-engineered polymeric scaffold system. It also can serve as a novel bone-inducing growth factor for repairing and regenerating bone tissues during bone regenerative engineering.


参考文献:
[1]Lo KW, Kan HM, Ashe KM, Laurencin CT.  The small molecule PKA-specific cyclic AMP analogue as an inducer of osteoblast-like cells differentiation and mineralization. J Tissue Eng Regen Med. 2012 Jan;6(1):40-8.
[2]Simone Kiermayer, Ricardo M.  Biondi,etal., Epac Activation Converts cAMP from a Proliferative into a Differentiation Signal in PC12 Cells. Molecular Biology of the Cell. Vol. 16, 5639–5648, December 2005.
[3]Cheng X, Ji Z, Tsalkova T, Mei F.   Epac and PKA: a tale of two intracellular cAMP receptors. Acta Biochim Biophys Sin (Shanghai). 2008 Jul;40(7):651-62.