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SZL P1-41
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SZL P1-41图片
CAS NO:222716-34-9
规格:98%
分子量:420.52
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Skp2 inhibitor
CAS:222716-34-9
分子式:C24H24N2O3S
分子量:420.52
纯度:98%
存储:Store at -20°C

Background:

SZL P1-41 is a specific Skp2 inhibitor, binds to the F-box domain of Skp2 to prevent Skp1 association and Skp2 SCF complex formation. SZL P1-41, like Skp2 deficiency, augments p27-mediated apoptosis/senescence, while it impairs Akt-driven glycolysis. Anti-tumor activities[1][2].


SZL P1-41 (5-20μM; 24 hours) induces endogenous p27 protein expression in PC3 cells and also induced expression of p21, another Skp2 substrate[1].


SZL P1-41 (40-80 mg/kg; i.p.) displays a potent effect on inhibiting prostate and lung tumor growth in Nude mice bearing A549 and PC3 tumor xenografts[1].


参考文献:
[1]. Chan CH et al. Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell. 2013 Aug 1;154(3):556-68.
[2]. Chan CH, et al. Skp2: a dream target in the coming age of cancer therapy. Cell Cycle. 2014;13(5):679-80.