PrPSc-IN-1 是荧光探探针,能够与错误折叠的朊病毒蛋白 PrPSc,抑制其聚集,IC50 值为 1.6 μM。具有抗阮病毒活性。
CAS:1315475-30-9
分子式:C22H17N5O
分子量:367.4
纯度:98%
存储:Store at -20°C
Background:
PrPSc-IN-1 is a fluorescent probe, binds to the misfolded protein PrPSc, inhibits its accumulation, with an IC50 of 1.6 μM. Anti-prion activity[1].
IC50:1.6 μM (PrPSc)[1]
[1]. Zaccagnini L, et al. Identification of novel fluorescent probes preventing PrPSc replication in prion diseases. Eur J Med Chem. 2017 Feb 15;127:859-873.