JNJ-37822681 dihydrochloride 是一种高效、特异性、有中枢活性的,能快速解离的多巴胺 D2 受体拮抗剂,对多巴胺 D2L 受体的亲和力适中 (Ki =158 nM),具有治疗精神分裂症和躁郁症的潜力。
CAS:2108806-02-4
分子式:C17H19Cl2F5N4
分子量:445.26
纯度:98%
存储:Store at -20°C
Background:
JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D2 receptor antagonist with a moderate binding affinity for the dopamine D2L receptor (Ki =158 nM), which has potential for the treatment of schizophrenia and bipolar disorder[1].
Ki: 158 nM (dopamine D(2))[1]
[1]. Langlois X, et al. Pharmacology of JNJ-37822681, a specific and fast-dissociating D2 antagonist for the treatment of schizophrenia. J Pharmacol Exp Ther. 2012 Jul;342(1):91-105.