您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Homocarbonyltopsentin
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Homocarbonyltopsentin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Homocarbonyltopsentin图片
CAS NO:172286-77-0
规格:98%
分子量:370.36
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Homocarbonyltopsentin (PK4C9) 是结合 TSL2 的小分子化合物,高羰基形成蛋白,与 TSL2 的 pentaloop 构象结合并促进向三叶草构象的转变,增强 SMN2 外显子7 (E7) 剪接,EC50 值为 16 μM。
CAS:172286-77-0
分子式:C21H14N4O3
分子量:370.36
纯度:98%
存储:Store at -20°C

Background:

Homocarbonyltopsentin (PK4C9) is a small-molecule TSL2-binding compound, binds to pentaloop conformations of TSL2 and promotes a shift to triloop conformations that display enhanced SMN2 exon 7 (E7) splicing with EC50 value of 16 μM[1].


Homocarbonyltopsentin (PK4C9) (10-40 μM; 24 hours) shows an up to 5.2-fold decrease in the expression of E7-excluding SMN2 isoforms, and up to three-fold increase in E7-including isoforms in GM03813C cells[1].Homocarbonyltopsentin (PK4C9) (40 μM; 24 hours) increased 1.5-fold SMN protein expression compared to GM03813C cells treated with DMSO[1]. RT-PCR[1] Cell Line: GM03813C (SMA) cells; GM03814B fibroblasts cells



[1]. Garcia-Lopez A, et al. Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes. Nat Commun. 2018 May 23;9(1):2032.