2614W94是具有选择性的，可逆的monoamineoxidase-A抑制剂，IC50值和Ki值分别为5nM和1.6nM。
CAS：205187-35-5
分子式：C15H11F3O4S
分子量：344.31
纯度：98%
存储：Store at -20°C

Background:

2614W94 is a selective, reversible inhibitor of monoamine oxidase-A with a competitive mechanism of inhibition and IC50 of 5 nM and Ki of 1.6 nM with serotonin as substrate.

2614W94 shows potent inhibitory activity against MAO-A, but shows no inhibition of MAO-B at 30 nM[1].

2614W94 (5 mg/kg, p.o.) produces selective inhibition of MAO-A in brains and livers of rats. 2614W94 (5 mg/kg, p.o.) also causes an elevation of neurotransmitter amines in brain, inparticular serotonin and norepinephrine, with a concomitant decrease in their oxidized metabolites. 2614W94 (0.5, 1, 2 mg/kg, p.o.) potentiates 5-hydroxytryptophan-induced head twitches in rats in a dose-dependent manner, with an extrapolated ED50 of 1.1 mg/kg[1].

[1]. Helen L. White, et al. Biochemical and Pharmacologic Properties of 2614W94, a Reversible, Competitive Inhibitor of MonoamineOxidase-A. DRUG DEVELOPMENT RESEARCH 45:1-9 (1998).