Astramembrangenin 环黄芪醇是一种三萜皂苷化合物，是黄芪 (Astragalus membranaceus (Fisch.) Bunge) 中活性成分的水解产物。Astramembrangenin 具有口服安全性，具有广泛的药理学作用，包括端粒酶活化，端粒延长，抗炎和抗氧化特性。Astramembrangenin 具有抗衰老特性，CAG 刺激人新生角质形成细胞和大鼠神经细胞中的端粒酶活性，并诱导 CREB 活化。 Astramembrangenin 可能在抑郁症中具有新的治疗作用。
CAS：78574-94-4
分子式：C30H50O5
分子量：490.72
纯度：98%
存储：Store at -20°C

Background:

Astramembrangenin (Cycloastragenol) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus (Fisch.) Bunge[1].Astramembrangenin is orally safe and has broad Extensive pharmacological effects, including telomerase activation, telomere elongation, anti-inflammatory and anti-oxidative properties[2].Astramembrangenin has antiaging properties, CAG stimulates telomerase activity in human neonatal keratinocytes and rat neuronal cells, and induces CREB activation followed by tert and bcl2 expression. Cycloastragenol (CAG) may have a novel therapeutic role in depression[2].

Astramembrangenin (0-10 µM; 3-6 days) increases cell growth compared to the vehicle control in HEK cultures[1].Astramembrangenin (0.3 µM; 5-90 mins) induces CREB phosphorylation in primary cortical neurons, total CREB expression is unaltered by CAG in both cell type[1].Astramembrangenin (3 µM; 6-48 hours) may promotes prosurvival signaling in neurons, increases tert mRNA expression, exhibits increased bcl2 mRNA expression[1]. Cell Viability Assay[1] Cell Line: HEK cells

[1]. Ip FC, et al. Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management. Neurosignals. 2014;22(1):52-63. [2]. Yu Y, et al. Cycloastragenol: An exciting novel candidate for age-associated diseases. Exp Ther Med. 2018 Sep;16(3):2175-2182. [3]. Sun C, et al. Cycloastragenol mediates activation and proliferation suppression in concanavalin A-induced mouse lymphocyte pan-activation model. Immunopharmacol Immunotoxicol. 2017 Jun;39(3):131-139.