I-CBP112是一种特异性和有效的乙酰-赖氨酸竞争性蛋白-蛋白相互作用抑制剂,靶向CBP/p300溴结构域,在白血病细胞中的IC50值为5.5±1.1μM。
CAS:1640282-31-0
分子式:C27H36N2O5
分子量:468.59
纯度:98%
存储:Store at -20°C
Background:
I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor, that targets the CBP/p300 bromodomains.
I-CBP112 significantly enhances acetylation by p300 at the histone H3K18 and H3K23 sites. I-CBP112 stimulated H3K18ac by