PF 05089771是出自专利WO/2010/079443 A1中的Nav1.7离子通道阻断剂,IC50值8.6nM。
CAS:1235403-62-9
分子式:C18H12Cl2FN5O3S2
分子量:500.35
纯度:98%
存储:Store at -20°C
Background:
PF 05089771 is a Nav1.7 channel blocker extracted from patent WO/2010/079443 A1, compound example 788, has an IC50 of 8.6 nM.
[1]. Norinder U, et al. QSAR investigation of NaV1.7 active compounds using the SVM/Signature approach and the Bioclipse Modeling platform. Bioorg Med Chem Lett. 2013 Jan 1;23(1):261-3.
[2]. BEAUDOIN, et al. SULFONAMIDE DERIVATIVES. Patent WO/2010/079443 A1.