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H-Val-Pro-Pro-OH(trifluoroactetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
H-Val-Pro-Pro-OH(trifluoroactetate salt)图片
规格:98%
分子量:311.4
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx22628
CAS:N/A
分子式:C15H25N3O4.XCF3COOH
分子量:311.4
溶解度:DMF: 15mg/mL,DMSO: 15mg/mL,Ethanol: 15mg/mL,PBS (pH 7.2): 10mg/mL
纯度:98%
存储:Store at -20°C
库存:现货

Background:

H-Val-Pro-Pro-OH (VPP) is a peptide inhibitor of angiotensin-converting enzyme (ACE; IC50= 9 µM).1It inhibits acetylcholine-induced nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs) when used at a concentration of 1 µM and induces vasorelaxation in precontracted isolated rat aortic rings.2VPP (0.3 mg/kg) decreases systolic blood pressure in spontaneously hypertensive, but not normotensive, rats.3Dietary administration of VPP reduces plasma levels of total cholesterol, HDL-cholesterol, and triglycerides, expression ofIl6andIl1b, and aortic arch intimal thickening and atherosclerotic plaque formation inApoE-/-mice.4


1.Nakamura, Y., Yamamoto, N., Sakai, K., et al.Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milkJ. Dairy Sci.78(4)777-783(1995) 2.Hirota, T., Nonaka, A., Matsushita, A., et al.Milk casein-derived tripeptides, VPP and IPP induced NO production in cultured endothelial cells and endothelium-dependent relaxation of isolated aortic ringsHeart Vessels26(5)549-556(2011) 3.Nakamura, Y., Yamamoto, N., Sakai, K., et al.Antihypertensive effect of sour milk and peptides isolated from it that are inhibitors to angiotensin I-converting enzymeJ. Dairy Sci.78(6)1253-1257(1995) 4.Nakamura, T., Hirota, T., Mizushima, K., et al.Milk-derived peptides, Val-Pro-Pro and Ile-Pro-Pro, attenuate atherosclerosis development in apolipoprotein e-deficient mice: A preliminary studyJ. Med. Food16(5)396-403(2013)