A DNA alkylating agent
货号:ajcx25890
CAS:N/A
分子式:C3H7N3O2 • XH2O
分子量：117.1
溶解度:DMF: 15 mg/mL,DMSO: 20 mg/mL,Ethanol: 20 mg/mL,PBS (pH 7.2): 3 mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

1-Ethyl-1-nitrosourea (ENU) is a DNA alkylating agent.¹It increases the concentrations of O⁶-ethylguanine, N⁷-ethylguanine, N⁷-ethyladenine, and N³-ethyladenine in rat brain. ENU (80 mg/kg) is teratogenicin vivo, inducing tumor formation and paw malformations in rat pups when administered to pregnant rats.²

1.Goth, R., and Rajewsky, M.F.Persistence of O6-ethylguanine in rat-brain DNA: Correlation with nervous system-specific carcinogenesis by ethylnitrosoureaProc. Natl. Acad. Sci. USA71(3)639-643(1974) 2.Druckrey, H., Ivankovi?, S., and Preussmann, R.Teratogenic and carcinogenic effects in the offspring after single injection of ethylnitrosourea to pregnant ratsNature210(5043)1378-1379(1966)