SB-633825 是有效的， ATP 竞争性的 TIE2，LOK (STK10) 和 BRK 抑制剂，IC50 分别为 3.5 nM，66 nM 和 150 nM。SB-633825 抑制癌细胞的生长和血管生成。
货号:ajcx29678
CAS:956613-01-7
分子式:C28H25N3O3S
分子量：483.58
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SB-633825 is a potent and ATP-competitive inhibitor of TIE2, LOK (STK10) and BRK with IC50s of 3.5 nM, 66 nM, 150 nM, respectively. SB-633825 can inhibit cancer cell growth and angiogenesis[1].

SB-633825 inhibits TIE2 Tyrosine-protein kinase (TIE2), lymphocyte-oriented kinase (LOK; STK10) and breast tumor kinase (Brk; PTK6)[1]. SB-633825 inhibits LOK to 44% maximal activity and TIE2 to 75% maximal activity at 0.1 µM[1].

[1]. Elkins JM, et al. Comprehensive characterization of the Published Kinase Inhibitor Set. Nat Biotechnol. 2016 Jan;34(1):95-103.