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Didemnin B
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Didemnin B图片
规格:98%
分子量:1112.4
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
Didemnin B 是一种从海洋被囊类动物 Trididemnin cyanophorum 中提取的缩肽。 Didemnin B 可用于癌症的研究。
货号:ajcx25284
CAS:77327-05-0
分子式:C57H89N7O15
分子量:1112.4
溶解度:Acetonitrile: 1 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Didemnin B is a depsipeptide that has been found in sea squirts and has diverse biological activities.1,2It reduces viral titers of coxsackievirus A21, equine rhinovirus, parainfluenza virus 3, herpes simplex virus 1 (HSV-1), and HSV-2 in infected Vero cells when used at a concentration of 50 µg/ml.1Didemnin B is cytotoxic to murine L1210 lymphocytic leukemia cells (IC50= 1.1 ng/ml) and increases survival time in a P388 murine leukemia model when administered at a dose of 0.06 mg/kg. It also reduces splenomegaly in a mouse model of graftversushost reaction (GVHR) when administered at doses ranging from 0.05 to 0.3 mg/kg.2


1.Rinehart, K.L., Jr., Gloer, J.B., Hughes, R.G., Jr., et al.Didemnins: Antiviral and antitumor depsipeptides from a Caribbean tunicateScience212(4497)933-935(1981) 2.Montgomery, D.W., and Zukoski, C.L.Didemnin B: A new immunosuppressive cyclic peptide with potent activity in vitro and in vivoTransplantation40(1)49-56(1985)